Any other 23andMe members?

[Chris74]

If so, has it shed any light on your current health situation?

 

I was just discussing yesterday Apo-E types WRT exercise types and also the possible dangers of being  Îµ4/ε4

and supplementing with Fish Oil.

 

Anyway, interested to see any others comments

[Chris74]

Some tasty background: (i am e2/e3) - e4 COULD be a major marker for the eventual onset of Alzheimers.

 

ApoE is polymorphic,^[7][8] with three major isoforms: ApoE2 (cys112, cys158), ApoE3 (cys112, arg158), and ApoE4 (arg112, arg158).^[9] Although these allelic forms differ from each other by only one or two amino acids at positions 112 and 158,^[10][11][12] these differences alter apoE structure and function. These have physiological consequences:

• E2 (rs7412) is found in approximately 7 percent of the population.^[13] This variant of the apoprotein binds poorly to cell surface receptors while E3 and E4 bind well.^[14] E2 is associated with both increased and decreased risk foratherosclerosis. Individuals with an E2/E2 combination may clear dietary fat slowly and be at greater risk for early vascular disease and the genetic disorder type III hyperlipoproteinemia—94.4% of such patients are E2/E2, while only ∼2% of E2/E2 develop the disease, so other environmental and genetic factors are likely to be involved (such as cholesterol in the diet and age).^[15][16][17] E2 has also been implicated in Parkinson's disease.^[18]
• E3 (rs429358) is found in approximately 79 percent of the population.^[13] It is considered the "neutral" Apo E genotype.
• E4 is found in approximately 14 percent of the population.^[13] E4 has been implicated in atherosclerosis,^[19] Alzheimer's disease,^[20][21] impaired cognitive function,^[22][23] reduced hippocampal volume,^[23] HIV,^[24] faster disease progression in multiple sclerosis,^[25] unfavorable outcome after traumatic brain injury,^[26] ischemic cerebrovascular disease,^[27] sleep apnea,^[28][29] and reduced neurite outgrowth.^[30]

[TrayS]

Chris, I am intrigued by 23andme and am gonna do it. The Alzheimer's markers are of primary concern for me particularly as my mom is now in her 60s, since it seems to run in my family. Can you share what information have you come across regarding dangers of supplementing with fish oil? I'd really like to take a look.

[Chris74]

Chris, I am intrigued by 23andme and am gonna do it. The Alzheimer's markers are of primary concern for me particularly as my mom is now in her 60s, since it seems to run in my family. Can you share what information have you come across regarding dangers of supplementing with fish oil? I'd really like to take a look.

 

<a data-ipb="nomediaparse" data-cke-saved-href="http://www.noaw.com/In%20Office%20Labs/O3" href="http://www.noaw.com/In%20Office%20Labs/O3" s0002.pdf"="">www.noaw.com/In%20Office%20Labs/O3's0002.pdf - copy and paste this link, the hook for it doesn't work

 

 

there's A LOT of info to look at and consider

I eat fish, not so much supplementing fish oil (not counting FCLO).  Better to keep the o6:o3 ratio close via diet than throwing tons of fish oil caps at it.

[Nila]

I am a 23andMe member. There are links between what I learned and what I'm currently experiencing in my health. I'll admit I haven't done enough deep investigative work so there's probably a lot more to be learned.

 

I do not have the APOE4 variant. I do, however, have a rather scary risk percentage for venous thromboembolism.

[Chris74]

whats a scary risk percentage?