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  1. I'm actually around the same time frame--Day 22-ish--and have the same thing going on. I did have a urinalysis performed and the results came back negative but I'm still having the same symptoms (two days into taking Macrobid). The nurse practitioner told me it's possible that I have interstitial cystitis or could have a vaginal (yeast) infection that's contributing to the issue since I apparently do not have a UTI. I've tried Whole30 one other time and around the 22-day mark that time, I experienced severe itchiness in my rectum, particularly after #2. Sorry if TMI, but one of the thing